By 1600 the Iroquois Confederacy is formed. It is a confederacy of Upper New York State Indians tribes.

The Iroquois break the Huron trading empire between the St. Lawrence River and Georgian Bay.

French Jesuits convert a number of Iroquois people, they separate from the Confederacy, settling along the St.Lawrence River near Montreal.

Mohawks, Onodagas, and Senecas agree to support the British against the French. The Onedias and Cayugas refuse to join them.

Four Mohawk chiefs visit Queen Anne of England. They declare their allegiance to the British crown.

The Tuscarora Nation joins the Iroquois Confederacy making it a Six Nations Confederacy.

Joseph Brant is born on the banks of the Ohio River.

November 5 - Treaty is signed at Fort Stanwix by the Six Nations and the British.

Sir William Johnson dies

Chief Joseph Brant joins Guy Johnson on a trip to England. Joseph Brant is well received and returns home even more devoted to the British cause in North America.

The American Revolution war between the British and the Americans for control of the colonies.

August 6 - The Battle of Oriskany Joseph Brant and his followers defeat an American militia army on its way to relieve the siege of Fort Stanwix.

July 3 - Wyoming Massacre. John Butler and Sayenqueraghta's Seneca warriors burn nearly 1000 houses and kill 227 rebels.

The Americans destroy 41 native villages and force them to flee to British Fort Niagara. The campaign was executed under the direction of General John Sullivan

October 22 - Second treaty at Fort Stanwix between the British and the Six Nations.

October 25 - Haldimand's Proclamation awards the Six Nations a tract of land six miles wide on either side of the Grand River from its source to its mouth.

Mohawk Village is built on a bend of the Grand River

The Jay Treaty formalizes the border between the United States and Canada

Seneca chief, Sganyadaiyoh (Handsome Lake), has a series of visions which yields the Gaiwiyo (The Good Message) urging the Iroquois to revert back to a more traditional way of life.

Chief Joseph Brant dies on November 24 at his home in Burlington, Ontario.

War of 1812. Iroquois warriors in the Niagara region fight for the British.

July 5 - Battle of Chippewa , in which the American Six Nations, under Red Jacket, fight against the Canadian Six Nations and the British under Major Norton.

The Six Nations gives up 800 acres for the site of the town of Brantford, Ontario.

Six Nations funds were invested in the Grand River Navigation Company without the approval of the Six Nations. The investment was a total disaster and the money was lost. Part of the Six Nations funds was also used for the founding of McGill University and the University of Toronto.

Six Nations surrender 20,000 acres on a recommendation by Samuel Peter Jarvis, Chief Superintendent of Indian Affairs.

Indian Act goes against Iroquois tradition by emphasizing male lineage and suppressing traditional forms of native government in favor of a system of non-traditionally elected Band Councils.

Province of Saskatchewan defined The North West Territory provisional districts of Assinboia, Saskatchewan and Athabaska became known as the province of Saskatchewan.

Many Iroquois enlist to fight in WWII.

The Six Nations declare war on the Axis powers, asserting its right as an independent sovereign nation.

A series of encroachments on upstate New York reservation lands leads to increased militancy among the Iroquois tribes, including the Mohawk, the Tuscarora, and the Seneca.

The Seneca learn that much of their land is about to be flooded by the proposed Kinzua Dam.

Kinzua Dam completed. It causes the flooding of Seneca lands in New York and destroys the burial place of Cornplanter, a great Seneca leader.

The Mohawk of the Akwesasne Reserve block the International Seaway Bridge between Massena, N.Y. in the U.S. and Cornwall, ON, Canada to draw attention to the violation of the Jay Treaty of 1794 by the government of Canada.

Mohawks protest the expansion of a golf course on tribal burial lands near Oka, Quebec.

Roberta Jamieson is the first female chief elected by the Six Nations.